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- Articled'Elia G, Hanson L, Raotma H.Acta Psychiatr Scand. 1978 Mar;57(3):239-52.Trials performed do not provide evidence for an antidepressant effect of 5-HTP. L-TP, without interacting pharmaca, does not appear to be a well-documented antidepressant. The only convincing evidence for L-TP as an antidepressant is that L-TP enhances the effect of MAOI.